Wnt1

WNT1
Identifiants
Alias	WNT1
IDs externes	OMIM: 164820 MGI: 98953 HomoloGene: 3963 GeneCards: WNT1
Position du gène (humain)
Chr.	Chromosome 12 humain
Fin	48,982,620 bp
Position du gène (souris)
Chr.	Chromosome 15 (souris)
Fin	98,691,718 bp
Expression génique
	Fortement exprimé dans
	granulocyte; ; noyau accumbens; ; gyrus frontal supérieur; ; right frontal lobe; ; cortex préfrontal; ; putamen; ; sang; ; noyau caudé; ; moelle osseuse; ; Brodmann area 9;
	Fortement exprimé dans
	muscle layer of urethra; ; pelvic part of vagina; ; rhombic lip; ; canal éjaculateur; ; perineal part of vagina; ; masse cellulaire interne; ; epithelium of seminiferous tubule of testis; ; choroid plexus of fourth ventricle; ; female urethra; ; morula;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	cytokine activity; protein domain specific binding; frizzled binding; morphogen activity; signaling receptor binding; receptor ligand activity;
Composant cellulaire	cytoplasme; endocytic vesicle membrane; endoplasmic reticulum lumen; membrane plasmique; région extracellulaire; surface cellulaire; Golgi lumen; exosome; milieu extracellulaire;
Processus biologique	negative regulation of cell-substrate adhesion; forebrain anterior/posterior pattern specification; dopaminergic neuron differentiation; neurogenèse; cell fate commitment; negative regulation of fat cell differentiation; positive regulation of protein phosphorylation; myotube differentiation; metencephalon development; midbrain-hindbrain boundary maturation during brain development; T cell differentiation in thymus; spinal cord association neuron differentiation; negative regulation of cell-cell adhesion; neuron fate determination; signal transduction in response to DNA damage; central nervous system morphogenesis; positive regulation of fibroblast proliferation; positive regulation of dermatome development; cell-cell signaling; negative regulation of cell differentiation; hematopoietic stem cell proliferation; cell proliferation in midbrain; positive regulation of DNA-binding transcription factor activity; embryonic axis specification; hepatocyte differentiation; negative regulation of transforming growth factor beta receptor signaling pathway; cerebellum development; ubiquitin-dependent SMAD protein catabolic process; cerebellum formation; negative regulation of BMP signaling pathway; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; régulation positive de la transcription dépendante de l'ADN; développent d'un organisme multicellulaire; diencephalon development; branching involved in ureteric bud morphogenesis; cellular response to peptide hormone stimulus; midbrain-hindbrain boundary development; embryonic brain development; response to wounding; positive regulation of insulin-like growth factor receptor signaling pathway; inner ear morphogenesis; animal organ regeneration; positive regulation of cell population proliferation; negative regulation of ubiquitin-dependent protein catabolic process; neuron fate commitment; myoblast fusion; positive regulation of lamellipodium assembly; développement osseux; Spemann organizer formation; midbrain development; positive regulation of Notch signaling pathway; positive regulation of transcription by RNA polymerase II; Voie de signalisation Wnt; astrocyte-dopaminergic neuron signaling; positive regulation of canonical Wnt signaling pathway; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; midbrain dopaminergic neuron differentiation; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; Wnt signaling pathway, planar cell polarity pathway; beta-catenin destruction complex disassembly; negative regulation of oxidative stress-induced neuron death; regulation of signaling receptor activity; canonical Wnt signaling pathway; negative regulation of apoptotic process; différenciation d'un neurone;
	Sources:Amigo / QuickGO
Orthologues
	7471
	22408
	ENSG00000125084
	ENSMUSG00000022997
	P04628
	P04426
	NM_005430
	NM_021279
	NP_005421
	NP_067254
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

Wnt1 est une protéine de la famille Wnt codée par le gène Wnt1.

Structure

Il s'agit d'une glycoprotéine dont le gène se situe sur le chromosome 12 humain.

Rôles

Elle intervient dans le développement du cerveau du fœtus^[5] et a un rôle dans le développement de certains cancers chez la souris par sa forme soluble^[6].

En médecine

Une mutation du gène peut entrainer une forme récessive d'ostéogenèse imparfaite ou une ostéoporose familiale précoce^[7].

Notes et références

GRCh38: Ensembl release 89: ENSG00000125084 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022997 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Thomas KR, Capecchi MR, Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development, Nature, 1990;346:847-850
↑ Bradley RS, Brown AM, A soluble form of Wnt-1 protein with mitogenic activity on mammary epithelial cells, Mol Cell Biol, 1995;15:4616-4622
↑ Laine CM, Kyu Sang Joeng, Campeau PM et al. WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta, N Engl J Med, 2013;368:1809-1816

Portail de la médecine
Portail de la biologie cellulaire et moléculaire

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125084 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022997 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Thomas_1990-5] Thomas KR, Capecchi MR, Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development, Nature, 1990;346:847-850

[Bradley_1995-6] Bradley RS, Brown AM, A soluble form of Wnt-1 protein with mitogenic activity on mammary epithelial cells, Mol Cell Biol, 1995;15:4616-4622

[Laine_2013-7] Laine CM, Kyu Sang Joeng, Campeau PM et al. WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta, N Engl J Med, 2013;368:1809-1816

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